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| Gimenes,A.C.; Bravo,D.M.; Nápolis,L.M.; Mello,M.T.; Oliveira,A.S.B.; Neder,J.A.; Nery,L.E.. |
| Exercise intolerance due to impaired oxidative metabolism is a prominent symptom in patients with mitochondrial myopathy (MM), but it is still uncertain whether L-carnitine supplementation is beneficial for patients with MM. The aim of our study was to investigate the effects of L-carnitine on exercise performance in MM. Twelve MM subjects (mean age±SD=35.4±10.8 years) with chronic progressive external ophthalmoplegia (CPEO) were first compared to 10 healthy controls (mean age±SD=29±7.8 years) before they were randomly assigned to receive L-carnitine supplementation (3 g/daily) or placebo in a double-blind crossover design. Clinical status, body composition, respiratory function tests, peripheral muscle strength (isokinetic and isometric torque) and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exercise tolerance; Muscle strength; Mitochondrial myopathy; L-carnitine supplementation. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400354 |
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| Mazzuco,A.; Souza,A.S.; Medeiros,W.M.; Sperandio,P.A.; Alencar,M.C.N.; Arbex,F.F.; Neder,J.A.; Borghi-Silva,A.. |
| The oxygen uptake (V˙O2) kinetics during onset of and recovery from exercise have been shown to provide valuable parameters regarding functional capacity of both chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) patients. To investigate the influence of comorbidity of COPD in patients with CHF with reduced ejection fraction on recovery from submaximal exercise, 9 CHF-COPD male patients and 10 age-, gender-, and left ventricle ejection fraction (LVEF)-matched CHF patients underwent constant-load exercise tests (CLET) at moderate and high loads. The V˙O2, heart rate (HR), and cardiac output (CO) recovery kinetics were determined for the monoexponential relationship between these variables and time. Within-group analysis showed that... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic heart failure; Chronic obstructive pulmonary disease; Oxygen uptake; Heart rate; Recovery kinetics; Exercise test. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000300602 |
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| Neder,J.A.; Andreoni,S.; Castelo-Filho,A.; Nery,L.E.. |
| Static lung volume (LV) measurements have a number of clinical and research applications; however, no previous studies have provided reference values for such tests using a healthy sample of the adult Brazilian population. With this as our main purpose, we prospectively evaluated 100 non-smoking subjects (50 males and 50 females), 20 to 80 years old, randomly selected from more than 8,000 individuals. Gender-specific linear prediction equations were developed by multiple regression analysis with total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), RV/TLC ratio and inspiratory capacity (IC) as dependent variables, and with age, height, weight, lean body mass and indexes of physical fitness as independent ones. Simpler... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lung volumes; Pulmonary function tests; Pulmonary diseases. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600006 |
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| Neder,J.A.; Andreoni,S.; Lerario,M.C.; Nery,L.E.. |
| The strength of the respiratory muscles can be evaluated from static measurements (maximal inspiratory and expiratory pressures, MIP and MEP) or inferred from dynamic maneuvers (maximal voluntary ventilation, MVV). Although these data could be suitable for a number of clinical and research applications, no previous studies have provided reference values for such tests using a healthy, randomly selected sample of the adult Brazilian population. With this main purpose, we prospectively evaluated 100 non-smoking subjects (50 males and 50 females), 20 to 80 years old, selected from more than 8,000 individuals. Gender-specific linear prediction equations for MIP, MEP and MVV were developed by multiple regression analysis: age and, secondarily, anthropometric... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Respiratory muscle strength; Maximal voluntary ventilation; Pulmonary function tests. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600007 |
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| Gimenes,A.C.; Neder,J.A.; Dal Corso,S.; Nogueira,C.R.; Nápolis,L.; Mello,M.T.; Bulle,A.S.; Nery,L.E.. |
| We determined the response characteristics and functional correlates of the dynamic relationship between the rate (Δ) of oxygen consumption ( <img border=0 width=11 height=13 src="548_files/image001.gif" v:shapes="_x0000_i1188">O2) and the applied power output (work rate = WR) during ramp-incremental exercise in patients with mitochondrial myopathy (MM). Fourteen patients (7 males, age 35.4 ± 10.8 years) with biopsy-proven MM and 10 sedentary controls (6 males, age 29.0 ± 7.8 years) took a ramp-incremental cycle ergometer test for the determination of the <img border=0 width=11 height=13 src="548_files/image001.gif" v:shapes="_x0000_i1189">O2 on-exercise mean response time (MRT) and the gas exchange threshold (GET). The Δ<img border=0... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Muscular diseases; Oxygen consumption; Cardiopulmonary exercise testing; Skeletal muscle; Pathophysiology; Mitochondrial myopathy. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400013 |
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